Citrus fruits, which are cultivated worldwide, have been recognized as some of the most high-consumption fruits in terms of energy, nutrients and health supplements. What is more, a number of these fruits have been used as traditional medicinal herbs to cure diseases in several Asian countries. Numerous studies have focused on Citrus secondary metabolites as well as bioactivities and have been intended to develop new chemotherapeutic or complementary medicine in recent decades. Citric acids from Citrus have been found to show anti-oxidant activity in lipopolysaccharide (LPS)-treated mice . Korani et al.  demonstrated that gallic acid has a beneficial activity against 2VO-induced cognitive deficits via enhancement of the cerebral anti-oxidant defense.
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