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Low nicotinamide levels are toxic, but so are high levels, so tight control may be necessary. Intra-neuronal nicotinamide levels may be a link between degeneration when too low, and carcinogenesis or developmental problems when too high via PARP depletion. A.C. Williams et al Parkinson’s disease: the first common neurological disease due to auto-intoxication? Q J Med 2005; 98:215–226
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